Article
Proteogenomics: Integrating Next-Generation Sequencing and Mass Spectrometry to Characterize Human Proteomic Variation.
Annual review of analytical chemistry (Palo Alto, Calif.) - 12 Jun 2016
Sheynkman Gloria M, Shortreed Michael R, Cesnik Anthony J, Smith Lloyd M
Abstract excerpt
Mass spectrometry-based proteomics has emerged as the leading method for detection, quantification, and characterization of proteins. Nearly all proteomic workflows rely on proteomic databases to identify peptides and proteins, but these databases typically contain a generic set of proteins that lack variations unique to a given sample, precluding their detection. Fortunately, proteogenomics enables the detection...
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