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Investigation of the Urinary Peptidome to Unravel Collagen Degradation in Health and Kidney Disease

30 Dec 2024

Abstract excerpt

Naturally occurring fragments of collagen type I alpha 1 chain (COL1A1) have been previously associated with chronic kidney disease (CKD), with some fragments showing positive and others negative associations. Using urinary peptidome data from healthy individuals (n = 1131) and CKD patients (n = 5585) this aspect was investigated in detail. Based on the hypothesis that many collagen peptides are derived not from...

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PMID: 39740102
DOI: 10.1002/pmic.202400279

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