Article

γ-secretase promotes postsynaptic maturation through the cleavage of a Wnt receptor

2020-11-18

Abstract excerpt

An emerging feature of neurodegenerative disease is synaptic dysfunction and loss, leading to the suggestion that mechanisms required for synaptic maturation may be linked to disease. Synaptic maturation requires the transmission of signals between nascent synaptic sites and the nucleus, but how these signals are generated is not well understood. We posit that proteolytic cleavage of receptors, which enables their...

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Literature Corpus work: ac0b8729-b3a9-5f74-9f04-4f153837ec4d
DOI: 10.1101/2020.11.18.387720

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