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Article

Endogenous ZAP is associated with altered Zika virus infection phenotype.

Virology journal - 9 Nov 2024

Le Nguyen Phuong Khanh, Singh Prince Pal, Sabir Ahmad Jawad, Trus Ivan, Karniychuk Uladzimir

Abstract excerpt

The zinc finger antiviral protein 1 (ZAP) has broad antiviral activity. ZAP is an interferon (IFN)-stimulated gene, which itself may enhance type I IFN antiviral response. In a previous study, Zika virus was identified as ZAP-resistant and not sensitive to ZAP antiviral activity. Here, we found that ZAP was associated with the inhibition of Zika virus in Vero cells, in the absence of a robust type I IFN system...

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Identifiers

PMID: 39522048
DOI: 10.1186/s12985-024-02557-x
PMCID: PMC11549788

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