Article

LRRK2 Suppresses Lysosome Degradative Activity in Macrophages and Microglia Through MiT-TFE Transcription Factor Inhibition

2022-12-18

Abstract excerpt

Cells maintain optimal levels of lysosome degradative activity to protect against pathogens, clear waste and generate nutrients. Here we show that LRRK2, a protein that is tightly linked to Parkinson’s disease, negatively regulates lysosome degradative activity in macrophages and microglia via a transcriptional mechanism. Depletion of LRRK2 and inhibition of LRRK2 kinase activity enhanced lysosomal proteolytic act...

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Identifiers and source

Literature Corpus work: abe75d07-ce9b-5385-8ef7-71ab91cca64b
DOI: 10.1101/2022.12.17.520834

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