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TFEB and TFE3: Linking Lysosomes to Cellular Adaptation to Stress

14 Jun 2016

Abstract excerpt

In recent years, our vision of lysosomes has drastically changed. Formerly considered to be mere degradative compartments, they are now recognized as key players in many cellular processes. The ability of lysosomes to respond to different stimuli revealed a complex and coordinated regulation of lysosomal gene expression. This review discusses the participation of the transcription factors TFEB and TFE3 in the...

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PMID: 27298091
DOI: 10.1146/annurev-cellbio-111315-125407

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