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Brain Disorders Due to Lysosomal Dysfunction

19 Apr 2016

Abstract excerpt

Recent studies of autophagic and lysosomal pathways have significantly changed our understanding of lysosomes; once thought to be simple degradative and recycling centers, lysosomes are now known to be organelles capable of influencing signal transduction, via the mammalian target of rapamycin complex 1 (mTORC1), and regulating gene expression, via transcription factor EB (TFEB) and other transcription factors....

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PMID: 27090953
DOI: 10.1146/annurev-neuro-070815-014031

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