Article

Urine cf-Nucleosomes: A Non-invasive Window into Human Physiology and Disease

2024-09-03

Abstract excerpt

Urine contains fragments of cell-free DNA, which hold valuable molecular insights into the processes occurring within the urinary system and the whole body. It is unknown whether these fragments are in the form of chromatin, as in the cell of origin, and whether they maintain the cell of origin chromatin modifications. Here, we examine these questions using cell-free chromatin immunoprecipitation followed by seque...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: abd85e30-4a34-59de-8766-3590f0c4b8b0
DOI: 10.1101/2024.09.01.610671

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Urine cf-Nucleosomes: A Non-invasive Window into Human Physiology and DiseaseDOI 10.1101/2024.09.01.610671Read

Sub-nucleosomal organization in urine cell-free DNASemantic proximity Read

ChIP-seq of plasma cell-free nucleosomes identifies cell-of-origin gene expression programsSemantic proximity Read

The potential use of urine cell free DNA as a marker for cancerSemantic proximity Read

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunitiesSemantic proximity Read

Cell free extrachromosomal circular DNA is common in human urineSemantic proximity Read

Simulating cell-free chromatin using preclinical models for cancer-specific biomarker discoverySemantic proximity Read

Structure and diversity of urinary cell-free DNA informative of host-pathogen interactions in human urinary tract infectionSemantic proximity Read

Urinary Biomarkers for Lung Cancer DetectionSemantic proximity Read

The urinary eccDNA landscape in prostate cancer reveals associations with genome instability and vital roles in cancer progression.Semantic proximity Read

Inference of tumor cell-specific transcription factor binding from cell-free DNA enables tumor subtype prediction and early detection of cancerSemantic proximity Read

A Cellular Reference Resource for the Mouse Urinary BladderSemantic proximity Read

Urinary cell-free DNA is a versatile analyte for monitoring infections of the urinary tractSemantic proximity Read