Article

Sub-nucleosomal organization in urine cell-free DNA

2019-07-11

Abstract excerpt

Cell-free DNA (cfDNA) in urine is a promising analyte for noninvasive diagnostics. However, urine cfDNA is highly fragmented and whether characteristics of these fragments reflect underlying genomic architecture is unknown. Here, we perform comprehensive characterization of fragmentation patterns in urine cfDNA. We show modal size and genome-wide distribution of urine cfDNA fragments are consistent with transient...

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Identifiers and source

Literature Corpus work: 62793bf5-a73b-55ae-a8b4-256c8e54fab5
DOI: 10.1101/696633

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