Article

Mathematical modelling of megakaryopoiesis in Mpl-deficient and continuously thrombopoietin-stimulated mice points to an unknown control mechanism

2020-05-31

Abstract excerpt

<h4>ABSTRACT</h4> Thrombopoietin (TPO) is the ligand of the Mpl receptor and the key regulator of megakaryopoiesis and platelet production. A loss or gain of the TPO-receptor function affects haematopoiesis and results in severe diseases in humans. Appropriate mouse strains are available to mimic both myeloproliferative neoplasm (MPN) and congenital amegakaryocytic thrombocytopenia (CAMT) resulting from TPO overe...

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Literature Corpus work: ab99ab45-cc59-518c-949d-5d1ccb842bd1
DOI: 10.1101/2020.05.29.123489

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