Article

SphK2/S1P promotes metastasis in triple negative breast cancer through PAK1/LIMK1/Cofilin1 signaling pathway

2020-07-17

Abstract excerpt

<title>Abstract</title> <p>Background: Triple negative breast cancer (TNBC) features poor prognosis which partialy attributed to the high metastasis rate. However, there is no effective target for systemic TNBC therapy due to the absence of estrogen, progesterone, and human epidermal growth factor 2 receptors (ER, PR, HER-2) up to date. In the present study, we evaluated the role of sphingosine kinase 2 (SphK2) a...

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Literature Corpus work: ab94ddb4-34f2-555c-b359-20ddb8ef60c3
DOI: 10.21203/rs.3.rs-43512/v1

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