SPHK1 potentiates colorectal cancer progression and metastasis via regulating autophagy mediated by TRAF6-induced ULK1 ubiquitination

Abstract excerpt

<title>Abstract</title> <p>A sphingolipid metabolite regulator, sphingosine kinase 1 (SPHK1), plays a critical role in the development of colorectal cancer (CRC). Studies had demonstrated that invasion and metastasis of CRC are promoted by SPHK1-driven autophagy. However, the exact mechanism of SPHK1 drives autophagy to promote tumor progression remains unclear. Here, immunohistochemical detection showed the expr...

Topics

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• Autophagy in Disease and Therapy
• Calcium signaling and nucleotide metabolism
• Cell Adhesion
• Colonic Neoplasms
• Endoplasmic Reticulum Stress and Disease
• Focal Adhesion Protein-Tyrosine Kinases
• Intercellular Adhesion Molecule-1
• Sphingolipid Metabolism and Signaling

Identifiers and source

Literature Corpus work

57479015-036a-5d8c-b099-bed53c7140ea

DOI

10.21203/rs.3.rs-3203773/v1