Article

STAMBPL1 promotes triple-negative breast cancer angiogenesis by upregulating the transcription of GRHL3/HIF1α/VEGFA via FOXO1

2024-04-23

Abstract excerpt

<title>Abstract</title> <p>Anti-angiogenesis is a crucial therapeutic strategy for triple-negative breast cancer (TNBC), but the current targeted drugs are insufficient to meet clinical requirements. Our study has discovered that silencing the deubiquitinating enzyme STAMBPL1 can effectively inhibit the growth and angiogenesis of TNBC xenografts in nude mice. STAMBPL1 promotes the expression of HIF1α/VEGFA in TNB...

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Literature Corpus work: 3d678206-3705-5353-b12a-a22878996f96
DOI: 10.21203/rs.3.rs-4274439/v1

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