Article

Aberrant striatal oscillations after dopamine loss in parkinsonian non-human primates

2019-05-26

Abstract excerpt

Dopamine depletion in Parkinson’s disease (PD) is associated with abnormal oscillatory activity in the cortico-basal ganglia network. However, the oscillatory pattern of striatal neurons in PD remains poorly defined. Here, we analyzed the local field potentials in one untreated and five MPTP-treated non-human primates (NHP) to model advanced PD. Augmented oscillatory activity in the alpha (8-13 Hz) and low-beta (1...

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Literature Corpus work: 8313953b-5eed-5ff2-ac3b-239b6baa4c09
DOI: 10.1101/650770

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