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Circular RNA profiling identifies <i>circ5078</i> as a <i>BMPR2</i> -derived regulator of endothelial proliferation and stress responses

2023-09-18

Abstract excerpt

Germline loss-of-function BMPR2 mutations are the leading genetic cause of pulmonary arterial hypertension (PAH) and are strongly linked to aberrant endothelial proliferation and impaired translational stress responses. While these effects are generally attributed to a loss of the type-II bone morphogenetic protein receptor (BMPR-II), we used circular RNA profiling to identify circ5078 as a new functional RNA de...

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Literature Corpus work
ab4f5821-68e5-5154-ae00-7ae55aefc631
DOI
10.1101/2023.09.18.556866
Open publication

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Circular RNA profiling identifies <i>circ5078</i> as a <i>BMPR2</i> -derived regulator of endothelial proliferation and stress responsesDOI 10.1101/2023.09.18.556866
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