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Article

Epigenetically regulated gene expression profiles reveal four molecular subtypes with prognostic and therapeutic implications in colorectal cancer.

Briefings in bioinformatics - 20 Jul 2021

Wang Xiaokang, Liu Jinfeng, Wang Danwen, Feng Maohui, Wu Xiongzhi

Abstract excerpt

Transcriptomic deregulation by epigenetic mechanisms plays a crucial role in the heterogeneous progression of colorectal cancer (CRC). Herein, we first demonstrated that the frequencies of the aberrancies of DNA methylation-correlated (METcor) and microRNA (miRNA)-correlated (MIRcor) genes were significantly co-regulated. Next, through integrative clustering of the expression profiles of METcor and MIRcor genes,...

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PMID: 33300554
DOI: 10.1093/bib/bbaa309

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