Article

CCDC32 stabilizes clathrin-coated pits and drives their invagination

2024-06-26

Abstract excerpt

Clathrin-mediated endocytosis (CME) is essential for maintaining cellular homeostasis. Previous studies have reported more than 50 CME accessory proteins; however, the mechanism driving the invagination of clathrin-coated pits (CCPs) remains elusive. We show by quantitative live cell imaging that siRNA-mediated knockdown of CCDC32, a poorly characterized endocytic accessory protein, leads to the accumulation of un...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ab27c0dd-bceb-5ceb-b431-a8008bb9ee85
DOI: 10.1101/2024.06.26.600785

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CCDC32 stabilizes clathrin-coated pits and drives their invaginationDOI 10.1101/2024.06.26.600785Read

Loss of function mutations in CCDC32 cause a congenital syndrome characterized by craniofacial, cardiac and neurodevelopmental anomalies.Semantic proximity Read

Cardiofacioneurodevelopmental syndrome: Report of a novel patient and expansion of the phenotype.Semantic proximity Read

Endocytic accessory proteins are functionally distinguished by their differential effects on the maturation of clathrin-coated pits.Semantic proximity Read

Genome-edited human stem cells expressing fluorescently labeled endocytic markers allow quantitative analysis of clathrin-mediated endocytosis during differentiationSemantic proximity Read

A novel disorder reveals clathrin heavy chain-22 is essential for human pain and touch development.Semantic proximity Read

FAM172A controls the nuclear import and alternative splicing function of AGO2Semantic proximity Read

Sterols lower energetic barriers of membrane bending and fission necessary for efficient clathrin mediated endocytosisSemantic proximity Read

Lowe Syndrome-linked endocytic adaptors direct membrane cycling kinetics with OCRL in <i>Dictyostelium discoideum</i>Semantic proximity Read

Molecular mechanism and physiological functions of clathrin-mediated endocytosis.Semantic proximity Read

Clathrin’s life beyond 40: Connecting biochemistry with physiology and diseaseSemantic proximity Read

Membrane-associated periodic skeleton regulates major forms of endocytosis in neurons through a signaling-driven positive feedback loopSemantic proximity Read

Contribution of the clathrin adaptor AP-1 subunit µ1 to acidic cluster protein sorting.Semantic proximity Read