Article

Lowe Syndrome-linked endocytic adaptors direct membrane cycling kinetics with OCRL in <i>Dictyostelium discoideum</i>

2019-04-24

Abstract excerpt

<h4>Summary</h4> Mutations of the inositol 5-phosphatase OCRL cause Lowe Syndrome (LS), characterized by congenital cataract, low IQ and defective kidney proximal tubule resorption. A key subset of LS mutants abolishes OCRL’s interactions with endocytic adaptors containing F&H peptide motifs. Converging unbiased methods examining human peptides and the unicellular phagocytic organism Dictyostelium discoideum , r...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 715e9b46-9415-5ee2-9399-3a18a750cbce
DOI: 10.1101/616664

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lowe Syndrome-linked endocytic adaptors direct membrane cycling kinetics with OCRL in <i>Dictyostelium discoideum</i>DOI 10.1101/616664Read

Regulation of phagocytosis in Dictyostelium by the inositol 5-phosphatase OCRL homolog Dd5P4.Semantic proximity Read

The PH domain proteins IPIP27A and B link OCRL1 to receptor recycling in the endocytic pathway.Semantic proximity Read

The cellular and physiological functions of the Lowe syndrome protein OCRL1.Semantic proximity Read

The 5-phosphatase OCRL in Lowe syndrome and Dent disease 2.Semantic proximity Read

Two closely related endocytic proteins that share a common OCRL-binding motif with APPL1Semantic proximity Read

A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway.Semantic proximity Read

Multiple Ciliary Localization Signals Control INPP5E Ciliary TargetingSemantic proximity Read

Compensatory Role of Inositol 5-Phosphatase INPP5B to OCRL in Primary Cilia Formation in Oculocerebrorenal Syndrome of LoweSemantic proximity Read

A diverse family of inositol 5-phosphatases playing a role in growth and development in Dictyostelium discoideum.Semantic proximity Read

A role for OCRL in glomerular function and disease.Semantic proximity Read

A Dictyostelium model for BPAN disease reveals a functional relationship between the WDR45/WIPI4 homolog Wdr45l and Vmp1 in the regulation of autophagy-associated PtdIns3P and ER stressSemantic proximity Read

A role of OCRL in clathrin-coated pit dynamics and uncoating revealed by studies of Lowe syndrome cells.Semantic proximity Read