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Article

Mechanisms of tumor heterogeneity in TACE-resistant liver cancer: Insights from single-cell and whole-exome sequencing.

Hepatology communications - 1 Jul 2025

Liu Jihan, Zhang Yue, Ran Wei, Yang Liang, Zhang Wang, Liu Zhaoyu

Abstract excerpt

BACKGROUND: HCC is a significant health concern. CTNNB1 mutations are implicated in HCC progression and resistance to transarterial chemoembolization (TACE), potentially through the ITGB1/PI3K/AKT pathway. METHODS: HCC was induced in mice using diethylnitrosamine, and TACE-resistant models were established. Tumor tissue analysis, single-cell and whole-exome sequencing identified gene mutations and cellular...

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Identifiers

PMID: 40489756
DOI: 10.1097/HC9.0000000000000705
PMCID: PMC12153283

Genes

CTNNB1
ITGB1
SPP1

Variants

Provenance

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