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Mechanisms of tumor heterogeneity in TACE-resistant liver cancer: Insights from single-cell and whole-exome sequencing

9 Jun 2025

Abstract excerpt

BACKGROUND: HCC is a significant health concern. CTNNB1 mutations are implicated in HCC progression and resistance to transarterial chemoembolization (TACE), potentially through the ITGB1/PI3K/AKT pathway. METHODS: HCC was induced in mice using diethylnitrosamine, and TACE-resistant models were established. Tumor tissue analysis, single-cell and whole-exome sequencing identified gene mutations and cellular...

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Hepatocellular Carcinoma Treatment and Prognosis
Hippo pathway signaling and YAP/TAZ
Liver physiology and pathology

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40489756
DOI: 10.1097/hc9.0000000000000705

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