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mRNA m5C Alteration in Azacitidine Demethylation Treatment of Acute Myeloid Leukemia

17 Dec 2024

Abstract excerpt

The DNA demethylating therapy with azacitidine (AZA) is a promising therapeutic strategy for elderly patients with acute myeloid leukemia (AML). AZA primarily inhibits DNA methylation, promotes cell differentiation and apoptosis in AML. However, as a cytosine nucleoside analog, AZA also has the potential to be incorporated into RNA molecules. To assess the impact of AZA on RNA m5C methylation during demethylating...

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PMID: 39688413
DOI: 10.1002/mc.23864

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