Article
Hdac3 is an epigenetic inhibitor of the cytotoxicity program in CD8 T cells.
The Journal of experimental medicine - 6 Jul 2020
Tay Rong En, Olawoyin Olamide, Cejas Paloma, Xie Yingtian, Meyer Clifford A, Ito Yoshinaga, Weng Qing Yu, Fisher David E, Long Henry W, Brown Myles, Kim Hye-Jung, Wucherpfennig Kai W
Abstract excerpt
Cytotoxic T cells play a key role in adaptive immunity by killing infected or cancerous cells. While the transcriptional control of CD8 T cell differentiation and effector function following T cell activation has been extensively studied, little is known about epigenetic regulation of these processes. Here we show that the histone deacetylase HDAC3 inhibits CD8 T cell cytotoxicity early during activation and is...
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