Article
Site-directed mutagenesis of the 1,3-β glucan synthase catalytic subunit of <i>Pneumocystis jirovecii</i> and susceptibility assays suggest its sensitivity to caspofungin
2018-06-07
Abstract excerpt
The echinocandin caspofungin inhibits the catalytic subunit Gsc1 of the enzymatic complex synthetizing 1,3-β glucan, an essential compound of the fungal wall. Studies in rodents showed that caspofungin can treat Pneumocystis infections. However, its efficacy against Pneumocystis jirovecii , the species infecting exclusively humans, remains controversial. The aim of this study was to assess the sensitivity to cas...
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Identifiers and source
- Literature Corpus work
- aaf2f9ab-8cd1-5952-86de-68ab6be0bbba
- DOI
- 10.1101/340281