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Article

Recapitulation in Saccharomyces cerevisiae of cytochrome b mutations conferring resistance to atovaquone in Pneumocystis jiroveci.

Antimicrobial agents and chemotherapy - 1 Sept 2003

Hill Philip, Kessl Jacques, Fisher Nicholas, Meshnick Steven, Trumpower Bernard L, Meunier Brigitte

Abstract excerpt

Pneumocystis jiroveci (human-derived P. carinii) is an opportunistic pathogenic fungus which causes pneumonia and is life-threatening in immunocompromised individuals. Spontaneously acquired resistance to atovaquone, a hydroxynaphthoquinone that is used to treat P. jiroveci infections, was linked to mutations in the mitochondrially encoded cytochrome b gene. Because P. jiroveci cannot be easily cultivated, we...

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Source

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Identifiers

PMID: 12936966
DOI: 10.1128/AAC.47.9.2725-2731.2003
PMCID: PMC182622

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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