Article

Tissue inflammation induced by constitutively active STING is mediated by enhanced TNF signaling

2024-04-29

Abstract excerpt

Constitutive activation of STING by gain-of-function mutations triggers manifestation of the systemic autoinflammatory disease STING-associated vasculopathy with onset in infancy (SAVI). In order to investigate the role of signaling by tumor necrosis factor (TNF) in SAVI, we used pharmacological inhibition and genetic inactivation of TNF receptors 1 and 2 in murine SAVI, which is characterized by T cell lymphopeni...

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Literature Corpus work: 2b7f59b4-829a-5bfa-ad49-124285946572
DOI: 10.1101/2024.04.25.591149

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