Article

Endothelial Cell Expression of STING <sup>V154M</sup> Gain-of-Function Mutation Delays the Resolution of UVB-induced Skin Injury

2025-07-18

Abstract excerpt

<h4>ABSTRACT</h4> Gain-of-function mutations in STimulator of INterferon Genes (STING) cause STING-Associated Vasculopathy with Onset in Infancy (SAVI), a rare autoinflammatory disease characterized by debilitating inflammatory lung disease and hallmark skin manifestations, such as chilblains and progressive, non-healing ulcers. Mice expressing the most common SAVI-associated variant STING V154M (VM) recapitulat...

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Literature Corpus work: 7b19072a-d604-5187-99e2-6d2adaa5f8a1
DOI: 10.1101/2025.07.14.664621

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