Article

Autophagy acts as a brake on obesity-related fibrosis by controlling purine nucleoside signalling

2024-09-17

Abstract excerpt

<h4>ABSTRACT</h4> A hallmark of obesity is a pathological expansion of white adipose tissue (WAT), accompanied by marked tissue dysfunction and fibrosis. Autophagy promotes adipocyte differentiation and lipid homeostasis, but its role in obese adipocytes and adipose tissue dysfunction remains incompletely understood. Here, we demonstrate that autophagy is a key tissue-specific regulator of WAT remodelling in diet...

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Literature Corpus work: f2969935-0be2-5bdb-95bd-3a47daaa79b3
DOI: 10.1101/2024.09.17.613382

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