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Rest, Repair, Repeat: The Complex Relationship of Autophagy and Sleep

21 May 2025

Abstract excerpt

Autophagy and sleep are two evolutionary conserved mechanisms across the animal kingdom. Autophagy is a pathway for the degradation of cytoplasmic material in the lysosome, playing important roles in the homeostasis and health of the organism. On the other hand, sleep is a homeostatically regulated state with numerous presumed essential roles, including the restoration of tissue and physiological functions, such...

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PMID: 40409707
DOI: 10.1016/j.jmb.2025.169227

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