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Article

Mechanistic insights into the hydrolysis and synthesis of ceramide by neutral ceramidase.

The Journal of biological chemistry - 3 Apr 2009

Inoue Tsuyoshi, Okino Nozomu, Kakuta Yoshimitsu, Hijikata Atsushi, Okano Hiroyuki, Goda Hatsumi M, Tani Motohiro, Sueyoshi Noriyuki, Kambayashi Kouji, Matsumura Hiroyoshi, Kai Yasushi, Ito Makoto

Abstract excerpt

Ceramidase (CDase; EC 3.5.1.23) hydrolyzes ceramide to generate sphingosine and fatty acid. The enzyme plays a regulatory role in a variety of physiological events in eukaryotes and also functions as an exotoxin in particular bacteria. The crystal structures of neutral CDase from Pseudomonas aeru...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19088069
DOI: 10.1074/jbc.M808232200
PMCID: PMC2666609

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19088069-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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