Article

The domain architecture of JBP1 suggests synergy between J-base DNA binding and thymidine hydroxylase activity

2018-12-20

Abstract excerpt

JBP1 (J-DNA Binding Protein 1) contributes to biosynthesis and maintenance of base J (β-D-glucosyl-hydroxymethyluracil), a modification of thymidine (T) confined to pathogenic protozoa. JBP1 has two known functional domains: an N-terminal thymidine hydroxylase (TH) homologous to the 5-methylcytosine hydroxylase domain in TET proteins; and a J-DNA binding domain (JDBD) that resides in the middle of JBP1. Here we sh...

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Literature Corpus work: aa978697-c756-5d4c-a716-8c0a55bf0ea5
DOI: 10.1101/502252

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