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Article

JBP1 and JBP2 are two distinct thymidine hydroxylases involved in J biosynthesis in genomic DNA of African trypanosomes.

Nucleic acids research - 1 Apr 2009

Cliffe Laura J, Kieft Rudo, Southern Timothy, Birkeland Shanda R, Marshall Marion, Sweeney Kate, Sabatini Robert

Abstract excerpt

Genomic DNA of African trypanosomes contains a hypermodified thymidine residue termed base J (beta-d-glucosyl-HOMedU). This modified base is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. The base is synthesized in a two-step pathway. Initially, a thymidine residue in DNA is hydroxylated by a thymidine hydroxylase (TH). This intermediate...

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PMID: 19136460
DOI: 10.1093/nar/gkn1067
PMCID: PMC2655668

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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