Article

Gut bacteria regulate the pathogenesis of Huntington’s disease in <i>Drosophila</i> model

2021-08-13

Abstract excerpt

Changes in the composition of gut microbiota are implicated in the pathogenesis of several neurodegenerative disorders. Here, we investigated whether gut bacteria affect the progression of Huntington’s disease (HD) in transgenic Drosophila melanogaster (fruit fly) models expressing human full-length or N-terminal fragments of mutant huntingtin (HTT) protein, here referred to as HD flies. We find that elimination...

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Identifiers and source

Literature Corpus work: 32fe15ef-9a72-5211-a186-10eede316753
DOI: 10.1101/2021.08.12.456124

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