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Identification of Therapeutic Gene Targets in Triple-Negative Breast Cancer: A Hybrid Approach Integrating Semidefinite Programming, Boolean Simulation, and Druggability Analysis

2025-11-06

Abstract excerpt

Triple-negative breast cancer (TNBC) represents a significant clinical challenge due to the absence of well-established molecular targets and resistance to conventional therapies. Identifying synergistic combinations of therapeutic targets requires computational approaches that integrate topological network analysis, experimental validation, and clinical applicability. This work proposes a hybrid methodology that...

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Literature Corpus work
aa7d24b0-ba65-5f9b-9cb6-35d266d63633
DOI
10.1101/2025.11.05.686831
Open publication

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Identification of Therapeutic Gene Targets in Triple-Negative Breast Cancer: A Hybrid Approach Integrating Semidefinite Programming, Boolean Simulation, and Druggability AnalysisDOI 10.1101/2025.11.05.686831
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