Article

Virtual patient analysis identifies strategies to improve the performance of predictive biomarkers for PD-1 blockade

2024-05-21

Abstract excerpt

Patients with metastatic triple-negative breast cancer (TNBC) show variable responses to PD-1 inhibition. Efficient patient selection by predictive biomarkers would be desirable, but is hindered by the limited performance of existing biomarkers. Here, we leveraged in-silico patient cohorts generated using a quantitative systems pharmacology model of metastatic TNBC, informed by transcriptomic and clinical data, to...

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Literature Corpus work: 7654c1d1-8b7b-536a-997f-e913c11f4637
DOI: 10.1101/2024.05.21.595235

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