Cancer network activity associated with therapeutic response and synergism.

doi:10.1186/s13073-016-0340-x

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Article

Cancer network activity associated with therapeutic response and synergism.

Genome medicine - 24 Aug 2016

Serra-Musach Jordi, Mateo Francesca, Capdevila-Busquets Eva, de Garibay Gorka Ruiz, Zhang Xiaohu, Guha Raj, Thomas Craig J, Grueso Judit, Villanueva Alberto, Jaeger Samira, Heyn Holger, Vizoso Miguel, Pérez Hector, Cordero Alex, Gonzalez-Suarez Eva, Esteller Manel, Moreno-Bueno Gema, Tjärnberg Andreas, Lázaro Conxi, Serra Violeta, Arribas Joaquín, Benson Mikael, Gustafsson Mika, Ferrer Marc, Aloy Patrick, Pujana Miquel Àngel

Abstract excerpt

BACKGROUND: Cancer patients often show no or only modest benefit from a given therapy. This major problem in oncology is generally attributed to the lack of specific predictive biomarkers, yet a global measure of cancer cell activity may support a comprehensive mechanistic understanding of therapy efficacy. We reasoned that network analysis of omic data could help to achieve this goal. METHODS: A measure of...

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PMID: 27553366
DOI: 10.1186/s13073-016-0340-x
PMCID: PMC4995628

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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