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A tumor-agnostic, topology-informed scoring framework for drug repurposing: application to CDK4/6 inhibitor resistance in HR+ breast cancer

2025-05-06

Abstract excerpt

<title>Abstract</title> <p>Resistance to cyclin-dependent kinase 4/6 (CDK4/6) inhibitors poses a critical obstacle in managing hormone receptor-positive (HR⁺) breast cancer, underscoring an urgent need for new therapeutic strategies. Here, we developed a novel, tumor-agnostic, network-based scoring framework integrating transcriptomics, protein–protein interaction (PPI) networks, and drug-target affinity data to...

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Literature Corpus work
36251ad1-13b5-5556-b8af-d5aa4a491fa4
DOI
10.21203/rs.3.rs-6447930/v1
Open publication

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A tumor-agnostic, topology-informed scoring framework for drug repurposing: application to CDK4/6 inhibitor resistance in HR+ breast cancerDOI 10.21203/rs.3.rs-6447930/v1
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