Back to search

Article

Endogenous IL-10 Contributes to Wound Healing and Regulates Tissue Repair

2022-03-15

Abstract excerpt

<h4>Background</h4> Interleukin-10 (IL-10) is essential in fetal regenerative wound healing and likewise promotes a regenerative phenotype in adult dermal wounds. However, the role of endogenous IL-10 in postnatal dermal wound healing is not well established. We sought to determine the role of IL-10 in murine full thickness, excisional wounds that are splinted to prevent contracture and mimic human patterns of wo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
aa775230-79ed-5ca8-a65c-a49d0969a61b
DOI
10.1101/2022.03.15.484452
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Endogenous IL-10 Contributes to Wound Healing and Regulates Tissue RepairDOI 10.1101/2022.03.15.484452
IL-10 overexpression decreases inflammatory mediators and promotes regenerative healing in an adult model of scar formation.Semantic proximity
Wound healing in developmentSemantic proximity
Modeling Wound Chronicity In Vivo: The Translational Challenge to Capture the Complexity of Chronic WoundsSemantic proximity
Modulation of the inflammatory response by increasing fetal wound size or interleukin-10 overexpression determines wound phenotype and scar formation.Semantic proximity
Surgical Approaches to Create Murine Models of Human Wound HealingSemantic proximity
Overexpression of IL-10 in Adipose Mesenchymal Stem Cells Promotes Wound Healing in Diabetic MiceSemantic proximity
Live imaging the Foreign Body Response reveals how dampening inflammation reduces fibrosisSemantic proximity
Impaired wound contraction in stromelysin-1-deficient mice.Semantic proximity
Myostatin-null mice exhibit delayed skin wound healing through the blockade of transforming growth factor-β signaling by decorinSemantic proximity
Laboratory and preclinical evaluation of a novel wound dressing patch for treatment of wounds in the elderlySemantic proximity
Mechanical offloading of incisional wounds is associated with transcriptional downregulation of inflammatory pathways in a large animal modelSemantic proximity
MC1R reduces scarring and rescues stalled healing in a preclinical chronic wound modelSemantic proximity
Select a neighboring publication to make it the new centre.