Mechanical offloading of incisional wounds is associated with transcriptional downregulation of inflammatory pathways in a large animal model

Abstract excerpt

Cutaneous scarring is a major source of morbidity and current therapies to mitigate scar formation remain ineffective. Although wound fibrosis and inflammation are highly linked, only recently have mechanical forces been implicated in these pathways. Our group has developed a topical polymer device that significantly reduces post-injury scar formation via the manipulation of mechanical forces. Here we extend...

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