Article
Modulation of the inflammatory response by increasing fetal wound size or interleukin-10 overexpression determines wound phenotype and scar formation.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society - 1 Jan 2000
Morris Michael W, Allukian Myron, Herdrich Benjamin J, Caskey Robert C, Zgheib Carlos, Xu Junwang, Dorsett-Martin Wanda, Mitchell Marc E, Liechty Kenneth W
Abstract excerpt
Wound size impacts the threshold between scarless regeneration and reparative healing in the fetus with increased inflammation showed in fetal scar formation. We hypothesized that increased fetal wound size increases pro-inflammatory and fibrotic genes with resultant inflammation and fibroplasia and that transition to scar formation could be reversed by overexpression of interleukin-10 (IL-10). To test this...
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