Article

Cellular stress in brain organoids is limited to a distinct and bioinformatically removable subpopulation

2022-03-12

Abstract excerpt

Organoids enable disease modeling in complex and structured human tissue, in vitro . Like most 3D models, they lack sufficient oxygen supply, leading to cellular stress. These negative effects are particularly prominent in complex models, like brain organoids, where they can prevent proper lineage commitment. Here, we analyze brain organoid and fetal single cell RNA sequencing (scRNAseq) data from published and n...

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Literature Corpus work: aa52d619-653e-54e6-bc7f-e86a8cb8b119
DOI: 10.1101/2022.03.11.483643

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