Article

Integration of human organoids single-cell transcriptomic profiles and human genetics repurposes critical cell type-specific drug targets for severe COVID-19

2023-07-03

Abstract excerpt

Human organoids recapitulate the cell type diversity and function of their primary organs holding tremendous potentials for basic and translational research. Advances in single-cell RNA sequencing (scRNA-seq) technology and genome-wide association study (GWAS) have accelerated the biological and therapeutic interpretation of trait-relevant cell types or states. Here, we constructed a computational framework to int...

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Literature Corpus work: a383f980-a219-5aa1-bcd6-e607d4ce8a8c
DOI: 10.1101/2023.07.03.23292161

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