Article

Suppression of PIK3CA-driven epileptiform activity by acute pathway control

2021-03-04

Abstract excerpt

<h4>ABSTRACT</h4> Patients harboring mutations in the PI3K-AKT-MTOR signaling pathway often develop a spectrum of neurodevelopmental disorders including epilepsy. A significant proportion of them remain unresponsive to conventional anti-seizure medications. Understanding mutation-specific pathophysiology is thus critical for molecularly targeted therapies. We previously determined that mouse models expressing pat...

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Literature Corpus work: aa2ae73b-ad4c-51cb-be9f-24fa78e92718
DOI: 10.1101/2021.03.03.433821

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