Article

Modeling mTORopathy-related epilepsy in cultured murine hippocampal neurons using the multi-electrode array

2024-04-30

Abstract excerpt

<h4>ABSTRACT</h4> The mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway is a ubiquitous cellular pathway. mTORopathies, a group of disorders characterized by hyperactivity of the mTORC1 pathway, illustrate the prominent role of the mTOR pathway in disease pathology, often profoundly affecting the central nervous system. One of the most debilitating symptoms of mTORopathies is drug-resistant epi...

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Literature Corpus work: bce10d8a-9f13-51be-b41e-cf9e886dd887
DOI: 10.1101/2024.04.29.591584

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