Article

Targeting the PI3K/AKT pathway overcomes enzalutamide resistance by inhibiting induction of the glucocorticoid receptor

2019-10-01

Abstract excerpt

<h4>ABSTRACT</h4> The PI3K-AKT pathway has pleiotropic effects, and its inhibition has long been of interest in the management of prostate cancer, where a compensatory increase in PI3K signaling has been reported following Androgen Receptor (AR) blockade. Prostate cancer cells can also bypass AR blockade through induction of other hormone receptors, in particular the glucocorticoid receptor (GR). Here we demonstr...

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Literature Corpus work: aa260c03-83df-5de6-aadf-39aad7e4080b
DOI: 10.1101/783803

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