Article

<i>TMPRSS2-ERG</i> confers resistance to antiandrogens: mechanism and therapeutic implications

2025-01-20

Abstract excerpt

Approximately 50% of prostate cancer (PCa) patients harbor fusions involving the TMPRSS2 and ERG genes. Despite this, tailored therapies targeting the fused gene, tERG , remain undeveloped. Our study analyzed biopsy samples from two clinical trials assessing the efficacies of androgen receptor (AR) signaling inhibitors (ARSIs). The results revealed that tERG promotes resistance to ARSIs and is associated with...

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Literature Corpus work: 3ea9e0d3-40fe-5499-beaa-8e53005aeee7
DOI: 10.1101/2025.01.17.633582

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