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Glucocorticoid receptor action in prostate cancer: the role of transcription factor crosstalk

4 Jul 2024

Abstract excerpt

Prostate cancer is one of the most prevalent malignancies and is primarily driven by aberrant androgen receptor (AR) signaling. While AR-targeted therapies form the cornerstone of prostate cancer treatment, they often inadvertently activate compensatory pathways, leading to therapy resistance. This resistance is frequently mediated through changes in transcription factor (TF) crosstalk, reshaping gene regulatory...

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Share to Estrogen and related hormone effects
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PMID: 39027480
DOI: 10.3389/fendo.2024.1437179

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