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Inhibition of AKT promotes FOXO3a-dependent apoptosis in prostate cancer

25 Feb 2016

Abstract excerpt

Growth factor-induced activation of protein kinase-B (PKB), also known as AKT, induces pro-survival signaling and inhibits activation of pro-apoptotic signaling molecules including the Forkhead box O-3a (FOXO3a) transcription factor and caspase in transformed prostate cells in vitro. Earlier we reported that Withaferin-A (WA), a small herbal molecule, induces pro-apoptotic response-4 (Par-4) mediated apoptosis in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26913603
DOI: 10.1038/cddis.2015.403

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