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Article

An ALS-associated mutation dysregulates microglia-derived extracellular microRNAs in a sex-specific manner.

Disease models & mechanisms - 1 May 2024

Christoforidou Eleni, Moody Libby, Joilin Greig, Simoes Fabio A, Gordon David, Talbot Kevin, Hafezparast Majid

Abstract excerpt

Evidence suggests the presence of microglial activation and microRNA (miRNA) dysregulation in amyotrophic lateral sclerosis (ALS), the most common form of adult motor neuron disease. However, few studies have investigated whether the miRNA dysregulation originates from microglia. Furthermore, TDP-43 (encoded by TARDBP), involved in miRNA biogenesis, aggregates in tissues of ∼98% of ALS cases. Thus, this study...

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Share to Amyotrophic Lateral Sclerosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38721655
DOI: 10.1242/dmm.050638
PMCID: PMC11152562

Genes

TARDBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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