Wnt5a-Induced Exosomes From Bone Marrow Mesenchymal Stem Cells Promote Spinal Cord Injury Repair by Modulating Immune Cell Phenotypes and Alleviating Neuroinflammation via the NF-κB Pathway.

doi:10.1002/cns.70834

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Wnt5a-Induced Exosomes From Bone Marrow Mesenchymal Stem Cells Promote Spinal Cord Injury Repair by Modulating Immune Cell Phenotypes and Alleviating Neuroinflammation via the NF-κB Pathway.

CNS neuroscience & therapeutics - 1 Apr 2026

Luo Dan, Feng Enhui, Chen Ling, Ni Ke, Luo Sheng, Ma Lin, Wu Yuting, Hu Zhifeng, Lin Dingkun, Zhang Binshan, Yin Chaoyi, Guo Da, Liang Chaolun, Li Xing

Abstract excerpt

OBJECTIVE: Spinal cord injury is a devastating neurological disorder. The transplantation of mesenchymal stem cell-derived exosomes has shown great promise. Wnt5a has been reported to promote neuronal differentiation and spinal cord regeneration. However, its mechanistic role when delivered via exosomes remains unclear. In the present study, the function and underlying mechanism of Wnt5a in promoting neuronal...

Topics

Animals
Exosomes
Spinal Cord Injuries
Wnt-5a Protein
Mesenchymal Stem Cells
Rats
NF-kappa B
Rats, Sprague-Dawley
Signal Transduction
Neuroinflammatory Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mesenchymal Stem Cell Transplantation

Male

Phenotype

Cells, Cultured

Cell Differentiation

Female

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Identifiers

PMID: 41885803
DOI: 10.1002/cns.70834
PMCID: PMC13140915

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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