Article

Mechanisms of Neuroimmune Interactions in Stress Physiology, Health Implications, and Emerging Therapeutic Targets.

2026-02-03

Abstract excerpt

Chronic stress provokes maladaptive neuroimmune responses that disrupt the balance between the central nervous system and immune regulation. Dysregulation of the hypothalamic pituitary adrenal (HPA) axis, sympathetic adrenal medullary (SAM) system, and peripheral immune circuits sustains microglial activation and pro-inflammatory cytokine release. The process is responsible for driving persistent neuroinflammation...

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Literature Corpus work: aa0d2de5-ea9a-5492-a8a8-79ef4c9b3a90
DOI: 10.12688/f1000research.174946.1

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