Article
Adolescent stress sensitizes the adult neuroimmune transcriptome and leads to sex-specific microglial and behavioral phenotypes.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Apr 2021
Bekhbat Mandakh, Mukhara Deepika, Dozmorov Mikhail G, Stansfield John C, Benusa Savannah D, Hyer Molly M, Rowson Sydney A, Kelly Sean D, Qin Zhaohui, Dupree Jeffrey L, Tharp Gregory K, Tansey Malú G, Neigh Gretchen N
Abstract excerpt
Adolescent exposure to chronic stress, a risk factor for mood disorders in adulthood, sensitizes the neuroinflammatory response to a subsequent immune challenge. We previously showed that chronic adolescent stress (CAS) in rats led to distinct patterns of neuroimmune priming in adult male and female rats. However, sex differences in the neuroimmune consequences of CAS and their underlying mechanisms are not fully...
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